Amyloid fibrils are protein polymers comprising identical monomer units (homopolymers). Functional amyloids play a beneficial role in a variety of physiologic processes (eg, long-term memory formation, gradual release of stored peptide hormones). Amyloidosis results from the accumulation of pathogenic amyloids—most of which are aggregates of misfolded proteins—in a variety of tissues. 

Amyloidosis is a rare disease that may happen because of an abnormal protein called amyloid and affects the functions of other important organs. This may affect the heart, kidney, liver, and spleen.